RNase 4

Supplier: New England Biolabs (NEB)

M1284L M1284S

CA77532-254EA 572 CAD

CA77532-254 CA77532-252

RNase 4

Enzymes

RNase 4 is a single-stranded RNA endonuclease that cleaves 3´ of uridine in uridine-purine sequences (cut sites: U/A and U/G). RNase 4 allows more targeted digestion of substrate RNA compared to single-nucleotide specific RNases like T1 (cut site: after G), RNase U2 (cut sites: after A and G), or bovine pancreatic RNase A (cut sites: after C and U). RNase 4 endonuclease activity tolerates uridine base modifications such as pseudo-, N1-methyl-pseudo-, dihydro-, and 5-methoxy-uridine species (Ψ, m1Ψ, D, and mo5U).

Endoribonuclease activity tolerates common RNA chemical modifications
Enhance analysis of mRNA 5′ cap identity and distribution

RNase 4 is a single-stranded endoribonuclease that cleaves RNA at uridine-purine (U/R) dinucleotide sites. Generate a larger population of uniquely mappable oligonucleotides for improved RNA sequence characterization by LC-MS/MS. Due to the chemical mechanism of RNase 4 endonucleolytic cleavage, product oligonucleotides contain heterogenous 3´ ends, where most species contain a linear 3´-phosphate or cyclic 2´,3´-phosphate.

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