Staurosporine (from Streptomyces species), Sigma-Aldrich®

Supplier: MilliporeSigma

Synonyms: (5S,6R,7R,9R)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one, Antibiotic AM-2282

569397-100UG 569397-250UG 569397-1MG

CA80057-524EA 451.75 CAD

CA80057-524 CA80057-526 CA95061-CA952

Staurosporine (from Streptomyces species), Sigma-Aldrich®

Staurosporine

A potent cell-permeable broad spectrum inhibitor of protein kinases

Inhibits CaM kinase (IC50=20nM), myosin light chain kinase (IC50=1.3nM), protein kinase A (IC50=7nM), protein kinase C (IC50=0.7nM), and protein kinase G (IC50=8.5nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.

Formula: C₂₈H₂₆N₄O₃
MW: 466.541 g/mol

MDL Number: MFCD18252446
CAS Number: 62996-74-1

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