Phorbol-12-myristate-13-acetate, Sigma-Aldrich®
Supplier: MilliporeSigma
524400-10MG
524400-1MG
524400-25MG
524400-5MG
CA80055-398EA
1153.02
CAD
CA80055-398
CA80055-400
CA80055-402
CA80055-404
Phorbol-12-myristate-13-acetate, Sigma-Aldrich®
Phorbol-12-myristate-13-acetate
Most commonly-used phorbol ester
Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the FAS antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.
Formula:
C₃₆H₅₆O₈ |
MDL Number:
MFCD00036736 CAS Number: 16561-29-8 |
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