Genistein, Sigma-Aldrich®

Supplier: MilliporeSigma

Synonyms: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, 4',6'-Dihydroxy-3-(4-hydroxyphenyl)benzo(e)oxacyclohex-2-en-4-on, 5,7-Dihydroxy-3-(4-hydroxyphenyl)chromen-4-one, 4',5,7-Trihydroxyisoflavone

345834-20MG 345834-50MG

CA80051-868EA 411.9 CAD

CA80051-868 CA80051-870

Genistein, Sigma-Aldrich®

Genistein

Inhibits protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50=2.6µM)

The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC50>350µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.

Formula: C₁₅H₁₀O₅
MW: 270.24 g/mol

MDL Number: MFCD00016952
CAS Number: 446-72-0

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