Calphostin C (from Cladosporium cladosporioides), Sigma-Aldrich®
Supplier: MilliporeSigma
Highly specific inhibitor of protein kinase C (IC50=50nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters
Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50>5µM), protein kinase A (IC50>50µM), protein kinase G (IC50>25µM), and p60v-src (IC50>50µM). Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires light for activation.
Formula:
C₄₄H₃₈O₁₄ |
MDL Number:
MFCD00133155 CAS Number: 121263-19-2 |
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