Calphostin C (from Cladosporium cladosporioides), Sigma-Aldrich®

Supplier: MilliporeSigma

208725-100UG 208725-50UG
CA80055-994EA 735.91 CAD
CA80055-994 CA80055-996
Calphostin C (from Cladosporium cladosporioides), Sigma-Aldrich®
Calphostin C

Highly specific inhibitor of protein kinase C (IC50=50nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters


Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50>5µM), protein kinase A (IC50>50µM), protein kinase G (IC50>25µM), and p60v-src (IC50>50µM). Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires light for activation.

Formula: C₄₄H₃₈O₁₄
MDL Number: MFCD00133155
CAS Number: 121263-19-2

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SPECIFICATIONS

Environmentally Preferable

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