Anti-SARS-CoV-2 RBD Human Monoclonal Antibody [clone: COV2109]

Supplier: Genscript

GenScript®

A02109-100 A02109-1

77007-486EA 631.56 CAD

77007-486 77007-552

Anti-SARS-CoV-2 RBD Human Monoclonal Antibody [clone: COV2109]

Antibodies

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus. It caused coronavirus disease in 2019 (COVID-19). SARS-CoV-2 contains glycosylated spike (S) protein, which is composed of S1 subunit and S2 subunit. The S1 contains a receptor-binding domain (RBD) that can bind to ACE2 receptor on target cells. Lineage B.1.351 (a.k.a. 20H/501Y.V2) is a variant of SARS-CoV-2. It has multiple mutations in the RBD, including K417N, E484K, N501Y. Lineage B.1.1.7 (a.k.a. 20I/501Y.V1) is also a variant of SARS-CoV-2 and has a mutation called N501Y in the RBD.SARS-CoV-2 Spike (E484) Neutralizing Antibody (COV2109) is produced from cell culture in vitro under conditions free from animal-derived components. The product is a humanized neutralizing antibody, recognizing E484 site of wild-type RBD. When E484 is mutated to E484K, the mutant RBD, such as RBD (B.1.351) as seen in Figure 1, can’t be recognized by the product.

High specificity
High affinity
High stability

Genscript offers site-specific neutralizing antibodies, neutralizing antibody standards, and control antibodies.

Type:
Antigen: SARS-CoV-2 RBD
Clonality: Monoclonal
Clone: COV2109
Conjugation:
Epitope:
Host: Human
Isotype: IgG1
Reactivity:

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