Methyl-4-hydroxybenzoate 99.0-102.0% (by acidimetry), EMPROVE® ESSENTIAL Ph. Eur., BP, JP, NF, FCC, SAFC®
Supplier: MilliporeSigma
Synonyms:
Methyl Parahydroxybenzoate
, Methyl 4-hydroxybenzoate
, 4-Hydroxybenzoic acid methyl ester
, Methylparaben
1.06757.9024
1.06757.5000
CA1.06757.5000EA
666.96
CAD
CA1.06757.5000
EM1.06757.9024
Methyl-4-hydroxybenzoate 99.0-102.0% (by acidimetry), EMPROVE® ESSENTIAL Ph. Eur., BP, JP, NF, FCC, SAFC®
Methyl 4-hydroxybenzoate
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1 to 3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated.
Formula:
HOC₆H₄CO₂CH₃ MW: 152.15 g/mol Melting Pt: 125...128 °C Density: 1.38 g/cm³ (20 °C) Storage Temperature: Ambient |
MDL Number:
MFCD00002352 CAS Number: 99-76-3 EINECS: 202-785-7 |
Specification Test Results
Assay (Acidimetric) | 99.0 - 102.0 % |
Assay (HPLC) | 99.0 - 100.5 % |
Identity | passes test |
Appearance of solution | passes test |
Acidic substances | passes test |
Melting range (lower value) | ≥ 125 °C |
Melting range (upper value) | ≤ 128 °C |
Heavy metals (as Pb) | ≤ 10 ppm |
As (Arsenic) | ≤ 3 ppm |
Cd (Cadmium) | ≤ 10 ppm |
Cu (Copper) | ≤ 10 ppm |
Hg (Mercury) | ≤ 1 ppm |
Pb (Lead) | ≤ 2 ppm |
Zn (Zinc) | ≤ 10 ppm |
Related substances (HPLC) | passes test |
p-Hydroxy benzoic acid | ≤ 0.5 % |
Sum of all impurities | ≤ 1.0 % |
Largest unspecified impurity | ≤ 0.5 % |
Methanol (HS-GC) | ≤ 3000 ppm |
Other residual solvents (ICH Q3C) | excluded by manufactoring process |
Sulfated ash | ≤ 0.05 % |
Loss on drying (80 °C) | ≤ 0.5 % |
Corresponds to Ph Eur, BP, JP, NF, FCC |
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