Methyl-4-hydroxybenzoate 99.0-102.0% (by acidimetry), EMPROVE® ESSENTIAL Ph. Eur., BP, JP, NF, FCC, SAFC®

Supplier: MilliporeSigma

Synonyms: Methyl ParahydroxybenzoateMethyl 4-hydroxybenzoate4-Hydroxybenzoic acid methyl esterMethylparaben

1.06757.9024 1.06757.5000
CA1.06757.5000EA 666.96 CAD
CA1.06757.5000 EM1.06757.9024
Methyl-4-hydroxybenzoate 99.0-102.0% (by acidimetry), EMPROVE® ESSENTIAL Ph. Eur., BP, JP, NF, FCC, SAFC®
Methyl 4-hydroxybenzoate

Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1 to 3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated.

Formula: HOC₆H₄CO₂CH₃
MW: 152.15 g/mol
Melting Pt: 125...128 °C
Density: 1.38 g/cm³ (20 °C)
Storage Temperature: Ambient
MDL Number: MFCD00002352
CAS Number: 99-76-3
EINECS: 202-785-7
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Specification Test Results

Assay (Acidimetric) 99.0 - 102.0 %
Assay (HPLC) 99.0 - 100.5 %
Identity passes test
Appearance of solution passes test
Acidic substances passes test
Melting range (lower value) ≥ 125 °C
Melting range (upper value) ≤ 128 °C
Heavy metals (as Pb) ≤ 10 ppm
As (Arsenic) ≤ 3 ppm
Cd (Cadmium) ≤ 10 ppm
Cu (Copper) ≤ 10 ppm
Hg (Mercury) ≤ 1 ppm
Pb (Lead) ≤ 2 ppm
Zn (Zinc) ≤ 10 ppm
Related substances (HPLC) passes test
p-Hydroxy benzoic acid ≤ 0.5 %
Sum of all impurities ≤ 1.0 %
Largest unspecified impurity ≤ 0.5 %
Methanol (HS-GC) ≤ 3000 ppm
Other residual solvents (ICH Q3C) excluded by manufactoring process
Sulfated ash ≤ 0.05 %
Loss on drying (80 °C) ≤ 0.5 %
Corresponds to Ph Eur, BP, JP, NF, FCC

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