Anti-HbB Mouse Monoclonal Antibody [Clone: 14G2.G11.F11]

Supplier: Rockland Immunochemical

Hemoglobin A (beta chain) antibody 25 µl

Hemoglobin A (beta chain) antibody 25 µl

200-301-GS4

76234-978EA 854.78 CAD

76234-978

Anti-HbB Mouse Monoclonal Antibody [Clone: 14G2.G11.F11]

Antibodies

HbA antibodies detect the hemoglobin beta subunit wild type variant A isoform. Functional adult hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (α2β2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA-2. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Perhaps the most significant mutation is the E6V in the beta subunit and the cause of SCD, but other relevant isoforms of Hb are observed. HbA antibody cross reacts with HbA-2 but does not react other forms Hb. This antibody is ideal for investigators involved in Cardiovascular and developmental biology research.

Anti-Hemoglobin A (beta chain) (MOUSE) antibody is suitable for use in Western Blotting. Specific conditions of reactivity should be optimized by the end user. Expect a band of approximately 16 kDa.

Type: Primary
Antigen: HbB
Clonality: Monoclonal
Clone: 14G2.G11.F11
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG2a lambda
Reactivity:

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