PARP1 (Internal) Antibody Combo Pack, Rockland Immunochemicals

Supplier: Rockland Immunochemicals

K-X51

76236-388EA 251.22 CAD

76236-388

PARP1 (Internal) Antibody Combo Pack, Rockland Immunochemicals

Assays Immunological Assays

Anti-PARP1 (internal) Antibody Combo Pack

Combo Pack contains:
200-401-X51S - Rabbit Anti-PARP1 (internal) Antibody
611-103-122-0100 - Goat Anti-Rabbit IgG Peroxidase Conjugated Secondary

PARP1 is the primary member of the poly(ADP-ribose) polymerase family, whose function is to signal DNA damage (and to recruit repair proteins) by PARylation. PARP1 is also involved in multiple cell death pathways, including apoptosis, necroptosis, autophagy, and a relatively new pathway termed parthanatos. It has been implicated in a new form of cell death termed parthanatos. PARP1 can also promote tissue survival by shifting the balance of cell death programs between autophagy and necrosis. Clinical studies have shown vulnerability to PARP inhibitors in DNA repair defective cancers. Anti-PARP1 (internal) antibody is useful for researchers interested in cellular processes including DNA damage, transcriptional control, and stem cell identity research.

Anti-PARP1 (internal) antibody with the matched secondary has been validated by western blotting and nanoimmunoassay (NIA). Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 113 kDa in size corresponding to PARP-1 by western blotting in the appropriate cell lysate or extract.

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