Rat Recombinant GDNF (from E. coli)

Supplier: Peprotech

AF-450-51-10UG AF-450-51-100UG AF-450-51-250UG AF-450-51-1MG

75999-674EA 601.9 CAD

75999-674 75999-678 75999-680 75999-684

Rat Recombinant GDNF (from E. coli)

Proteins and Peptides

Animal-free

GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional rat GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration. The calculated molecular weight of Recombinant Rat GDNF is 30.0 kDa.

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