Human;Mouse;Rat Recombinant Irisin (from CHO cells)

Supplier: Peprotech

100-65-10UG 250-40-5UG 250-40-20UG 250-40-100UG 250-40-250UG 250-40-500UG 250-40-1MG

75999-404EA 512.11 CAD

75999-404 75999-534 75999-536 75999-538 75999-540 75999-542 75999-544

Human;Mouse;Rat Recombinant Irisin (from CHO cells)

Proteins and Peptides

Irisin is a proteolytic hormone released into circulation by skeletal muscle tissue during acute exercise, and is a derivative of the cleaved plasma membrane protein Fibronectin type III domain containing protein 5 (FNDC5). Found in muscle tissue, FNDC5 is synthesized at increased levels during exercise as a result of the overexpression of the exercise-responsive transcriptional co-activator PGC-1α (peroxisome proliferator-activated receptor-γ co-activator-1α). Like its parent polypeptide, Irisin can induce the browning of subcutaneous adipocytes, or the conversion of white adipose tissue (WAT or white fat) into brown (or beige) adipose tissue (BAT or brown fat). Given that brown fat can undergo thermogenesis, or the physiologic process of heat production, Irisin contributes to the metabolic process by increasing thermogenic function and glucose homeostasis. Irisin, thus, represents a link between exercise and “burning” of fats and/or sugars, and consequently may have relevance in the development of new treatments for diabetes and obesity.

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