ß-Nicotinamide adenine dinucleotide phosphate (NADP-Na2, oxidized form) ≥98%, white powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
1-((2R,3R,4S,5R)-5-((((((((2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-3-carbamoylpyridin-1-ium, disodium salt
, NADP disodium salt
, Triphosphopyridine nucleotide, disodium salt
, Nicotinamide-adenine dinucleotide phosphate disodium salt
, NADP-Na2
, β-NADP-Na2
, Nadide phosphate disodium salt
, β-NADH phosphate disodium salt
β-NADP is a coenzyme necessary for the alcoholic fermentation of glucose and the oxidative dehydrogenation of other substances. It occurs widely in living tissue, especially in the liver. Nicotinic acid can be converted to nicotinamide in the body and, in this form, is found as a component of two oxidation-reduction coenzymes: nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). The nicotinamide portion of the coenzyme transfers hydrogens by alternating between oxidized quaternary nitrogen and a reduced tertiary nitrogen. NADP is an essential coenzyme for glucose-6-phosphate dehydrogenase which catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconic acid. This reaction initiates metabolism of glucose by a pathway other than the citric acid cycle. This route is known as the hexose phosphate shunt or phosphogluconate pathway. Other enzymes which utilize NADP as a coenzyme are: Alcohol dehydrogenase:NADP dependent; Aromatic ADH:NADP dependent; Ferredoxin-NADP reductase; L-Fucose dehydrogenase; Gabase; Galactose-1-phosphate uridyl transferase; Glucose dehydrogenase; L-Glutamic dehydrogenase; Glycerol dehydrogenase:NADP specific; Isocitric dehydrogenase; Malic enzymes; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase and Succinic semialdehyde dehydrogenase.
- Extinction Coefficient (E1%): EmM (260 nm): 18.0 (0.1 M phosphate, pH 7.0)
- UV/Visible Absorbance: λmax (water) 258 - 260 nm
- Presentation: White Powder
- Solubility : Soluble in water (50 mg/mL- clear, colorless to slight yellowish solution) or methanol; less soluble in ethanol; practically insoluble in ether and ethyl acetate.
Storage: protect from light, under nitrogen.
Formula:
C₂₁H₂₆N₇Na₂O₁₇P₃ MW: 787.37 g/mol Melting Pt: 166...176 °C Storage Temperature: Refrigerator |
MDL Number:
MFCD00065390 CAS Number: 24292-60-2 |
Specification Test Results
Identity Test | Passes |
Purity |
|
FTIR | Conforms to Standard |
UV/Vis: l max (water) | 258 - 260 nm |
OD280/OD260 | 0.15 - 0.28 |
OD250/OD260 | 0.80 - 0.89 |
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