Anti-FOXP3 Mouse Monoclonal Antibody (Brilliant Violet 421™) [clone: 206D]

Supplier: Biolegend

320123 320124

CA75780-380EA 343.1 CAD

CA75780-380 CA75780-626

Anti-FOXP3 Mouse Monoclonal Antibody (Brilliant Violet 421™) [clone: 206D]

Antibodies

FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T
regulatory cells than most cell surface markers (such as CD4 and CD25).

Transduced expression of FOXP3 in CD4 /CD25 cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked
autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice.

Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human,
unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 206D antibody recognizes human FOXP3 epitope in the region of amino acids 105-235.

Type: Primary
Antigen: FOXP3
Clonality:
Clone: 206D
Conjugation: Brilliant Violet 421™
Epitope: 105-235
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Cynomolgus, Rhesus, Baboon, Pigtailed Macaque

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