Withaferin A (from Withania somnifera), Calbiochem®

Supplier: MilliporeSigma

681535-1MG 681535-5MG

CA80016-610EA 421.58 CAD

CA80016-610 CA80016-612

Withaferin A (from Withania somnifera), Calbiochem®

Withaferin A

Angiogenesis inhibitor.

White solid in form
Purity: ≥94% (by HPLC)

A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.

Isolated from Withania somnifera.

Packaging: Packaged under inert gas.

Formula: C₂₈H₃₈O₆

CAS Number: 5119-48-2

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