Anti-FCGR3A Mouse Monoclonal Antibody (Biotin) [clone: ICO-116]

Supplier: Biotium

BNCB1225-100 BNCB1225-500

75888-590EA 325.12 CAD

75888-590 75888-592

Anti-FCGR3A Mouse Monoclonal Antibody (Biotin) [clone: ICO-116]

Antibodies

This antibody recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

Type: Primary
Antigen: FCGR3A
Clonality: Monoclonal
Clone: Clone ICO-116
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human

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