Anti-HLA-DRB1 Mouse Monoclonal Antibody (CF568) [clone: LN-3 HLA-DRB/1067]

Supplier: Biotium

BNC681208-100 BNC681208-500

75951-412EA 325.12 CAD

75951-412 75951-414

Anti-HLA-DRB1 Mouse Monoclonal Antibody (CF568) [clone: LN-3 HLA-DRB/1067]

Antibodies

This MAb reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Type: Primary
Antigen: HLA-DRB1
Clonality: Monoclonal
Clone: Clone LN-3 HLA-DRB/1067
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Human, Monkey

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