Anti-CCNB1 Mouse Monoclonal Antibody (CF568) [clone: CCNB1/1098]

Supplier: Biotium

BNC681098-100 BNC681098-500

75921-516EA 325.12 CAD

75921-516 75921-518

Anti-CCNB1 Mouse Monoclonal Antibody (CF568) [clone: CCNB1/1098]

Antibodies

This antibody recognizes a protein of 55-62 kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Type: Primary
Antigen: CCNB1
Clonality: Monoclonal
Clone: Clone CCNB1/1098
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Mouse

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