Anti-PTPRC Mouse Monoclonal Antibody (Biotin) [clone: DF-B1]

Supplier: Biotium

BNCB1066-100 BNCB1066-500

75913-214EA 325.12 CAD

75913-214 75913-216

Anti-PTPRC Mouse Monoclonal Antibody (Biotin) [clone: DF-B1]

Antibodies

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin. This antigen is also expressed on the surface of cells of myeloid lineage.

Type: Primary
Antigen: PTPRC
Clonality: Monoclonal
Clone: Clone DF-B1
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG3 kappa
Reactivity: Human

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