Anti-PTPRC Mouse Monoclonal Antibody (CF647) [clone: DF-B1]

Supplier: Biotium

BNC471066-100 BNC471066-500

75913-250EA 325.12 CAD

75913-250 75913-252

Anti-PTPRC Mouse Monoclonal Antibody (CF647) [clone: DF-B1]

Antibodies

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin. This antigen is also expressed on the surface of cells of myeloid lineage.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Type: Primary
Antigen: PTPRC
Clonality: Monoclonal
Clone: DF-B1
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG3, kappa
Reactivity: Human

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