Anti-CPS1 Mouse Monoclonal Antibody [clone: CPS1/1022]

Supplier: Biotium

BNUB1022-100 BNUB1022-500

75951-058EA 380.65 CAD

75951-058 75951-060

Anti-CPS1 Mouse Monoclonal Antibody [clone: CPS1/1022]

Antibodies

This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

Type: Primary
Antigen: CPS1
Clonality: Monoclonal
Clone: Clone CPS1/1022
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Dog, Human

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