Anti-SOX10 Mouse Monoclonal Antibody (CF647) [clone: SOX10/992]

Supplier: Biotium

BNC470992-100 BNC470992-500
75975-752EA 325.12 CAD
75975-752 75975-754
Anti-SOX10 Mouse Monoclonal Antibody (CF647) [clone: SOX10/992]
Antibodies
This antibody recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Type: Primary
Antigen: SOX10
Clonality: Monoclonal
Clone: Clone SOX10/992
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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