Anti-CDKN1A Mouse Monoclonal Antibody (Biotin) [clone: HJ21]

Supplier: Biotium

BNCB0984-100 BNCB0984-500

75966-972EA 325.12 CAD

75966-972 75966-974

Anti-CDKN1A Mouse Monoclonal Antibody (Biotin) [clone: HJ21]

Antibodies

This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. It is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

Type: Primary
Antigen: CDKN1A
Clonality: Monoclonal
Clone: Clone HJ21
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Chimpanzee, Human, Monkey, Mouse, Rat

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