Anti-CDKN1A Mouse Monoclonal Antibody (CF647) [clone: HJ21]

Supplier: Biotium

BNC470984-100 BNC470984-500

75967-008EA 325.12 CAD

75967-008 75967-010

Anti-CDKN1A Mouse Monoclonal Antibody (CF647) [clone: HJ21]

Antibodies

This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. It is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Type: Primary
Antigen: CDKN1A
Clonality: Monoclonal
Clone: Clone HJ21
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Chimpanzee, Human, Monkey, Mouse, Rat

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