Anti-TFGB Mouse Monoclonal Antibody (Biotin) [clone: 1D11.16.8]

Supplier: Biotium

BNCB0977-100 BNCB0977-500

75976-420EA 325.12 CAD

75976-420 75976-422

Anti-TFGB Mouse Monoclonal Antibody (Biotin) [clone: 1D11.16.8]

This MAb recognizes TGF beta 1, 2 and 3. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80% identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGF betas inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.

Type: Primary
Antigen: TFGB
Clonality: Monoclonal
Clone: Clone 1D11.16.8
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Cow, Dog, Hamster, Human, Monkey, Mouse, Rat

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