Anti-MUC1 Mouse Monoclonal Antibody (CF640R) [clone: MUC1/967]

Supplier: Biotium

BNC400967-100 BNC400967-500
75963-766EA 325.12 CAD
75963-766 75963-768
Anti-MUC1 Mouse Monoclonal Antibody (CF640R) [clone: MUC1/967]
Antibodies
This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Type: Primary
Antigen: MUC1
Clonality: Monoclonal
Clone: Clone MUC1/967
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human
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