Anti-MUC1 Mouse Monoclonal Antibody (CF640R) [clone: MUC1/955]

Supplier: Biotium

BNC400955-100 BNC400955-500
75963-890EA 325.12 CAD
75963-890 75963-892
Anti-MUC1 Mouse Monoclonal Antibody (CF640R) [clone: MUC1/955]
Antibodies
This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Type: Primary
Antigen: MUC1
Clonality: Monoclonal
Clone: Clone MUC1/955
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Mouse
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