Anti-MUC1 Mouse Monoclonal Antibody (Biotin) [clone: HMPV]

Supplier: Biotium

BNCB0954-100 BNCB0954-500

75963-622EA 325.12 CAD

75963-622 75963-624

Anti-MUC1 Mouse Monoclonal Antibody (Biotin) [clone: HMPV]

Antibodies

This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.

Type: Primary
Antigen: MUC1
Clonality: Monoclonal
Clone: Clone HMPV
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human

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