Anti-CD46 Mouse Monoclonal Antibody (CF640R) [clone: 197-2B1]

Supplier: Biotium

BNC400931-100 BNC400931-500

75914-912EA 325.12 CAD

75914-912 75914-914

Anti-CD46 Mouse Monoclonal Antibody (CF640R) [clone: 197-2B1]

Antibodies

This antibody recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. This MAb can be applied to test complement activation in pseudo-allergic reactions to acetylsalicylic acid and to test for measles virus infection of cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Type: Primary
Antigen: CD46
Clonality: Monoclonal
Clone: Clone 197-2B1
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human

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