Anti-FCGR3A Mouse Monoclonal Antibody (CF405S) [clone: HuNK2]

Supplier: Biotium

BNC040928-100 BNC040928-500

75888-554EA 325.12 CAD

75888-554 75888-556

Anti-FCGR3A Mouse Monoclonal Antibody (CF405S) [clone: HuNK2]

Antibodies

This antibody recognizes a protein of 50-65 kDa, identified as CD16 (Workshop IV; Code N39 ) (also known low affinity Fc receptor III for IgG (FcRIII) or Leu 11). CD16 exists as a polypepetide-anchored from (FCRIIIA or CD16A) on human natural killer (NK) cells and monocytes/ macrophages and as a glycosylphosphatidylinositol (GPI)-anchored form (FcRIIIB or CD16B) on neutrophils. CD16B is polymorphic and the two alleles are termed NA1 and NA2.3 CD16 plays a role in signal transduction, NK cell activation and antibody-dependent cellular cytotoxicity. This MAb has been showed to inhibit the binding of immune complex to NK cells, inhibit cytotoxicity of NK cells, and induce calcium fluxes in NK cells and neutrophils.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Type: Primary
Antigen: FCGR3A
Clonality: Monoclonal
Clone: HuNK2
Conjugation: CF405S
Epitope:
Host: Mouse
Reactivity: Human
Isotype: IgG2a, kappa

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