Anti-PTH Mouse Monoclonal Antibody (Biotin) [clone: PTH/911]

Supplier: Biotium

BNCB0911-100 BNCB0911-500

75972-848EA 325.12 CAD

75972-848 75972-850

Anti-PTH Mouse Monoclonal Antibody (Biotin) [clone: PTH/911]

Antibodies

The epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Type: Primary
Antigen: PTH
Clonality: Monoclonal
Clone: Clone PTH/911
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human

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