Anti-TP53 Mouse Monoclonal Antibody (CF488A) [clone: TRP/817]

Supplier: Biotium

BNC880817-100 BNC880817-500

75967-700EA 325.12 CAD

75967-700 75967-702

Anti-TP53 Mouse Monoclonal Antibody (CF488A) [clone: TRP/817]

Antibodies

This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: TP53
Clonality: Monoclonal
Clone: Clone TRP/817
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human

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