Anti-CCND1 Mouse Monoclonal Antibody (CF568) [clone: CCND1/809]

Supplier: Biotium

BNC680809-100 BNC680809-500

75925-020EA 325.12 CAD

75925-020 75925-022

Anti-CCND1 Mouse Monoclonal Antibody (CF568) [clone: CCND1/809]

Antibodies

This antibody recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Type: Primary
Antigen: CCND1
Clonality: Monoclonal
Clone: Clone CCND1/809
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human

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