Anti-CCND1 Mouse Monoclonal Antibody (CF640R) [clone: CCND1/809]

Supplier: Biotium

BNC400809-100 BNC400809-500

75925-028EA 325.12 CAD

75925-028 75925-030

Anti-CCND1 Mouse Monoclonal Antibody (CF640R) [clone: CCND1/809]

Antibodies

This antibody recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Type: Primary
Antigen: CCND1
Clonality: Monoclonal
Clone: Clone CCND1/809
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human

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