Anti-KRT17 Mouse Monoclonal Antibody (CF594) [clone: KRT17/778]

Supplier: Biotium

BNC940778-100 BNC940778-500
75916-356EA 325.12 CAD
75916-356 75917-038
Anti-KRT17 Mouse Monoclonal Antibody (CF594) [clone: KRT17/778]
Antibodies
Cytokeratin 17 (CK17) is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as an epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Type: Primary
Antigen: KRT17
Clonality: Monoclonal
Clone: Clone KRT17/778
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Cow, Goat, Human, Pig, Rat
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