Anti-NEFH & NEFL Mouse Monoclonal Antibody (CF594) [clone: NF421 NFL/736]

Supplier: Biotium

BNC940756-100 BNC940756-500

75965-754EA 325.12 CAD

75965-754 75965-756

Anti-NEFH & NEFL Mouse Monoclonal Antibody (CF594) [clone: NF421 NFL/736]

Antibodies

This MAb reacts with a 200 kDa and 68 kDa protein, identified as heavy and light sub-units of neurofilaments (NF-H & NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68 kDa (NF-L), 160 kDa (NF-M) and 200 kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Type: Primary
Antigen: NEFH & NEFL
Clonality: Monoclonal
Clone: Clone NF421 NFL/736
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Chicken, Human, Mouse, Pig, Rat

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