Anti-NEFH & NEFL Mouse Monoclonal Antibody (CF488A) [clone: NF421 NFL/736]

Supplier: Biotium

BNC880756-100 BNC880756-500

75965-250EA 325.12 CAD

75965-250 75965-252

Anti-NEFH & NEFL Mouse Monoclonal Antibody (CF488A) [clone: NF421 NFL/736]

Antibodies

This MAb reacts with a 200 kDa and 68 kDa protein, identified as heavy and light sub-units of neurofilaments (NF-H & NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68 kDa (NF-L), 160 kDa (NF-M) and 200 kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: NEFH & NEFL
Clonality: Monoclonal
Clone: Clone NF421 NFL/736
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Chicken, Human, Mouse, Pig, Rat

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