Anti-PTPRC Mouse Monoclonal Antibody (CF647) [clone: 2B11 PD7/26]

Supplier: Biotium

BNC470745-500 BNC470745-100

75912-608EA 900.17 CAD

75912-608 75914-740

Anti-PTPRC Mouse Monoclonal Antibody (CF647) [clone: 2B11 PD7/26]

Antibodies

This antibody recognizes the CD45 leukocyte common antigen (LCA) family which comprises at least four isoforms of membrane glycoproteins (220, 205, 190, 180 kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portions of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. A positive result with this MAb is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Type: Primary
Antigen: PTPRC
Clonality: Monoclonal
Clone: Clone 2B11 PD7/26
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Dog, Human

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