Anti-TP53 Mouse Monoclonal Antibody (Biotin) [clone: BP53-12 DO-7]

Supplier: Biotium

BNCB0723-100 BNCB0723-500

75969-092EA 325.12 CAD

75969-092 75969-094

Anti-TP53 Mouse Monoclonal Antibody (Biotin) [clone: BP53-12 DO-7]

Antibodies

This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Type: Primary
Antigen: TP53
Clonality: Monoclonal
Clone: Clone BP53-12 DO-7
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgGs
Reactivity: Cow, Human, Monkey

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