Anti-CD1A Mouse Monoclonal Antibody (Biotin) [clone: O10 C1A/711]

Supplier: Biotium

BNCB0717-100 BNCB0717-500

75889-882EA 325.12 CAD

75889-882 75889-884

Anti-CD1A Mouse Monoclonal Antibody (Biotin) [clone: O10 C1A/711]

Antibodies

At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).

Type: Primary
Antigen: CD1A
Clonality: Monoclonal
Clone: Clone O10 C1A/711
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Human

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