Anti-TYMS Mouse Monoclonal Antibody (Biotin) [clone: TMS715]

Supplier: Biotium

BNCB0715-100 BNCB0715-500

75978-312EA 325.12 CAD

75978-312 75978-314

Anti-TYMS Mouse Monoclonal Antibody (Biotin) [clone: TMS715]

Antibodies

This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Type: Primary
Antigen: TYMS
Clonality: Monoclonal
Clone: Clone TMS715
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human

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