Anti-NKX2-1 Mouse Monoclonal Antibody [clone: NX2.1/690]

Supplier: Biotium

BNUB0690-100 BNUB0690-500

75978-226EA 380.65 CAD

75978-226 75978-228

Anti-NKX2-1 Mouse Monoclonal Antibody [clone: NX2.1/690]

Antibodies

This antibody recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Type: Primary
Antigen: NKX2-1
Clonality: Monoclonal
Clone: Clone NX2.1/690
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Mouse, Rat

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