Anti-ESR2 Mouse Monoclonal Antibody (Biotin) [clone: ESR2/686]

Supplier: Biotium

BNCB0686-100 BNCB0686-500

75926-092EA 325.12 CAD

75926-092 75926-094

Anti-ESR2 Mouse Monoclonal Antibody (Biotin) [clone: ESR2/686]

Antibodies

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Type: Primary
Antigen: ESR2
Clonality: Monoclonal
Clone: Clone ESR2/686
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Human

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