Anti-CD34 Mouse Monoclonal Antibody (CF660R) [clone: QBEnd/10]

Supplier: Biotium

BNC610640-100 BNC610640-500
75894-614EA 325.12 CAD
75894-614 75894-616
Anti-CD34 Mouse Monoclonal Antibody (CF660R) [clone: QBEnd/10]
Antibodies
This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120 kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified intothree main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain.CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi's sarcoma, but with a lower specificity.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®660R is a far-red fluorescent dye (Ex/Em 663/682 nm) with superior brightness and unrivaled photostability among spectrally similar dyes.

Type: Primary
Antigen: CD34
Clonality: Monoclonal
Clone: Clone QBEnd/10
Conjugation: CF660R
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Cynomolgus monkey, Human, Rhesus monkey
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