Anti-H1 Mouse Monoclonal Antibody (Biotin) [clone: 1415--1]

Supplier: Biotium

BNCB0580-100 BNCB0580-500

75950-554EA 325.12 CAD

75950-554 75950-556

Anti-H1 Mouse Monoclonal Antibody (Biotin) [clone: 1415--1]

Antibodies

Eukaryotic histones are basic and water-soluble nuclear proteins. They form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.

Type: Primary
Antigen: H1
Clonality: Monoclonal
Clone: Clone 1415--1
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human, Mouse, Rat

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