Anti-TOP1MT Mouse Monoclonal Antibody (CF405S) [clone: TOP1MT/488]

Supplier: Biotium

BNC040488-100 BNC040488-500

75977-340EA 325.12 CAD

75977-340 75977-342

Anti-TOP1MT Mouse Monoclonal Antibody (CF405S) [clone: TOP1MT/488]

Antibodies

DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Type: Primary
Antigen: TOP1MT
Clonality: Monoclonal
Clone: Clone TOP1MT/488
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human

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