Anti-PTPRC Mouse Monoclonal Antibody (Biotin) [clone: 2B11]

Supplier: Biotium

BNCB0470-100 BNCB0470-500

75912-810EA 325.12 CAD

75912-810 75912-812

Anti-PTPRC Mouse Monoclonal Antibody (Biotin) [clone: 2B11]

Antibodies

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

Type: Primary
Antigen: PTPRC
Clonality: Monoclonal
Clone: Clone 2B11
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human

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