Anti-ESR2 Mouse Monoclonal Antibody (CF568) [clone: ERb455]

Supplier: Biotium

BNC680455-100 BNC680455-500

75926-064EA 325.12 CAD

75926-064 75926-066

Anti-ESR2 Mouse Monoclonal Antibody (CF568) [clone: ERb455]

Antibodies

Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Type: Primary
Antigen: ESR2
Clonality: Monoclonal
Clone: Clone ERb455
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Horse, Human, Monkey, Mouse, Pig, Rat, Sheep

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