Anti-NKX2-1 Mouse Monoclonal Antibody (Biotin) [clone: 8G7G3/1]

Supplier: Biotium

BNCB0448-100 BNCB0448-500

75978-092EA 325.12 CAD

75978-092 75978-094

Anti-NKX2-1 Mouse Monoclonal Antibody (Biotin) [clone: 8G7G3/1]

Antibodies

This antibody recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Type: Primary
Antigen: NKX2-1
Clonality: Monoclonal
Clone: Clone 8G7G3/1
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Mouse, Rat

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